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I was getting about 350 miles per tank and all of a sudden I am getting only 220.

 
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that sucks

 
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Something could be wrong with the Engine or transmission. I'm no car junkie, but it sounds like your car is working alot harder. (Using more gas to power the engine)

 
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It could be a bad O2 sensor! This is what helps filter the gas! I would use some fuel injection cleaner! Honda's usually use 87 octane gas but I would fill it up with premium gas and put the treatment in it to help clean out your injectors! Its inexpensive, so it really couldn't hurt to see if that is the problem! Also use premium gas every fourth fill up or so!